John Adams Selected Research

APD791

6/2010

Discovery and structure-activity relationship of 3-methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): a highly selective 5-hydroxytryptamine2A receptor inverse agonist for the treatment of arterial thrombosis.

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John Adams Research Topics

Disease

19	Type 2 Diabetes Mellitus (MODY) 01/2022 - 08/2011
6	Insulin Resistance 01/2022 - 01/2017
6	Infections 01/2020 - 12/2007
2	Parasitemia 06/2022 - 01/2020
2	Burns 05/2022 - 05/2022
2	Colitis 01/2022 - 01/2019
2	Body Weight (Weight, Body) 01/2020 - 01/2020
2	Neurobehavioral Manifestations 10/2012 - 09/2012
2	Hypertension (High Blood Pressure) 08/2011 - 12/2004
2	Heart Failure 12/2004 - 05/2004
2	Wounds and Injuries (Trauma) 09/2004 - 04/2004
2	Dementia (Dementias) 06/2003 - 05/2002
1	Vivax Malaria 06/2022
1	Drug-Related Side Effects and Adverse Reactions 05/2022
1	Critical Illness (Critically Ill) 05/2022
1	Acute-Phase Reaction 05/2022
1	Iron Deficiencies 05/2022
1	Fibrosis (Cirrhosis) 01/2022
1	Hypersensitivity (Allergy) 01/2022
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2022
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2022
1	Abdominal Pain (Pain, Abdominal) 01/2022
1	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 01/2022
1	Non-alcoholic Fatty Liver Disease 01/2022
1	Systolic Heart Failure 02/2021
1	COVID-19 01/2020
1	Weight Loss (Weight Reduction) 01/2020
1	Pulmonary Arterial Hypertension 10/2019
1	Inflammation (Inflammations) 01/2019
1	Ulcerative Colitis 01/2019
1	Weight Gain 03/2017
1	Hypoglycemia (Reactive Hypoglycemia) 03/2017
1	Neoplasms (Cancer) 06/2015
1	Death (Near-Death Experience) 06/2015
1	Colorectal Neoplasms (Colorectal Cancer) 06/2015
1	Communicable Diseases (Infectious Diseases) 08/2014
1	Learning Disabilities (Learning Disability) 07/2014

Drug/Important Bio-Agent (IBA)

13	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 08/2011
7	Insulin (Novolin)FDA Link 01/2022 - 01/2017
7	Metformin (Glucophage)FDA LinkGeneric 01/2022 - 09/2013
7	Exenatide (Byetta)FDA Link 01/2022 - 01/2017
6	Pioglitazone (Actos)FDA Link 01/2022 - 01/2017
4	Pharmaceutical PreparationsIBA 01/2022 - 12/2004
3	CanagliflozinIBA 10/2020 - 01/2018
3	Liraglutide FDA Link 10/2020 - 01/2018
3	empagliflozinIBA 01/2018 - 01/2017
2	IronIBA 05/2022 - 05/2022
2	C-PeptideIBA 01/2022 - 01/2018
2	Glipizide (Glucotrol)FDA LinkGeneric 01/2022 - 01/2021
2	Messenger RNA (mRNA)IBA 01/2022 - 02/2007
2	Sodium-Glucose Transporter 2 InhibitorsIBA 01/2022 - 01/2020
2	dapagliflozinIBA 01/2022 - 10/2020
1	Transferrin Receptors (Transferrin Receptor)IBA 06/2022
1	VaccinesIBA 06/2022
1	Plasmodium vivax reticulocyte-binding proteinIBA 06/2022
1	Recombinant ProteinsIBA 06/2022
1	Transferrin (beta 2 Transferrin)IBA 05/2022
1	Ferritins (Ferritin)IBA 05/2022
1	Sulfonic AcidsIBA 01/2022
1	olorinabIBA 01/2022
1	nitrobenzeneIBA 01/2022
1	fibroblast growth factor 21IBA 01/2022
1	Alanine Transaminase (SGPT)IBA 01/2022
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2022
1	CarbohydratesIBA 01/2022
1	Protons (Proton)IBA 01/2022
1	Cannabinoid Receptors (Cannabinoid Receptor)IBA 01/2022
1	Dipeptidyl-Peptidase IV InhibitorsIBA 10/2020
1	Sodium-Glucose Transport ProteinsIBA 10/2020
1	saxagliptin FDA Link 10/2020
1	Ivermectin (Mectizan)FDA Link 01/2020
1	Chloroquine (Aralen)FDA LinkGeneric 01/2020
1	ProstaglandinsIBA 10/2019
1	ralinepagIBA 10/2019
1	Epoprostenol ReceptorsIBA 10/2019
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2019
1	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 01/2019
1	etrasimodIBA 01/2019
1	Sphingosine-1-Phosphate ReceptorsIBA 01/2019
1	LysophospholipidsIBA 01/2019
1	Bromocriptine (Parlodel)FDA LinkGeneric 10/2018
1	Glucagon-Like Peptide-1 Receptor AgonistsIBA 10/2018
1	SodiumIBA 01/2018
1	Levofloxacin (Levaquin)FDA Link 01/2018
1	Anti-Infective Agents (Microbicides)IBA 01/2018
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2018
1	Glucagon (Glukagon)FDA Link 01/2017
1	KetonesIBA 01/2017
1	Nonesterified Fatty Acids (NEFA)IBA 01/2017
1	SolutionsIBA 01/2015
1	Tetracycline (Achromycin)FDA LinkGeneric 08/2014

Therapy/Procedure

14	Therapeutics 05/2022 - 05/2002
3	Terminal Care (Care, Terminal) 10/2012 - 11/2003
2	Denervation 01/2020 - 04/2006
2	Home Nursing (Nursing, Home) 04/2004 - 06/2003
1	Blood Transfusion (Blood Transfusions) 05/2022
1	Intravenous Infusions 02/2021
1	Aftercare (After-Treatment) 01/2017
1	Drug Therapy (Chemotherapy) 06/2015
1	Hospice Care (Care, Bereavement) 06/2015